Research Publications
Welcome to the Meyer Stem Cell Lab's research publications page. Here, we provide a list of our latest publications in the field of stem cell research in neurodegeneration for glaucoma, Alzheimer's disease, and other neurodegenerative disorders.
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Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor
Anbukkarasi Muniyandi, Gabriella D Hartman, Kamakshi Sishtla, Ratan Rai, Cátia Gomes, Kristina Day, Yang Song, Andi R Masters, Sara K Quinney, Xiaoping Qi, Hailey Woods, Michael E Boulton, Jason S Meyer, Jonah Z Vilseck, Millie M Georgiadis, Mark R Kelley, Timothy W Corson
Angiogenesis. 2025 Jan 5;28(1):11. doi: 10.1007/s10456-024-09966-0.
Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit
Sailee Lavekar, Jason Hughes, Cátia Gomes, Jade Harkin, Scott Canfield, Jason S. Meyer​
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Fluids Barriers CNS. 2024 Nov 14;21(1):90. doi: 10.1186/s12987-024-00593-x.
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption & mTORC1 reduction
Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kiratin B. VanderWall, Sailee S Lavekar, Clarisse M. Fligor, Jade Harkin, Shelby Hetzer, Shruti V. Patil, Adriana Di Polo, Jason S. Meyer​
Acta Neuropathol Commun. 2024 Oct 18;12(1):164.doi: 10.1186/s40478-024-01872-2.
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models
Cátia Gomes, Kang-Chieh Huang, Jade Harkin, Aaron Baker, Jason M. Hughes, Yanling Pan, Kaylee Tutrow, Kirstin B. VanderWall, Sailee S. Lavekar, Melody Hernandez, Theodore R. Cummins, Scott G. Canfield, Jason S. Meyer​
Stem Cell Reports 2024 Aug 1; https://doi.org/10.1016/j.stemcr.2024.07.002.
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A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells
Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI
Laurel A Screven, Caroline B Pantazis, Katherine M Andersh, Samantha Hong, Dan Vitale, Erika Lara, Ray Yueh Ku, Peter Heutink, Jason Meyer, Kelley Faber, Kwangski Nho, Andrew J Saykin, Tatiana M Foroud, Mike A Nalls, Cornelis Blauwendraat, Andrew Singleton, Priyanka S Narayan
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Neuron. 2024 Mar 6;112(5):694-697. doi: 10.1016/j.neuron.2024.01.026.
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease
Sailee S. Lavekar, Jade Harkin, Melody Hernandez, Cátia Gomes, Shruti Patil, Kang-Chieh Huang, Shweta S. Puntambekar, Bruce T. Lamb, Jason S. Meyer
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Scientific Reports, 2023 Aug 24;13(1):13827. doi: 10.1038/s41598-023-40382-4.
The importance of unambiguous cell origin determination in neuronal repopulation studies
Thomas V Johnson, David J Calkins, Brad Fortune, Jeffrey L Goldberg, Anna La Torre, Deepak A Lamba, Jason S Meyer, Thomas A Reh, Valerie A Wallace, Donald J Zack, Petr Baranov
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iScience. 2023 Mar 9;26(4):106361. doi: 10.1016/j.isci.2023.106361. eCollection 2023 Apr 21.
Retinal Ganglion Cells in a Dish: Current Strategies and Recommended Best Practices for Effective In Vitro Modeling of Development and Disease
Kang-Chieh Huang, Cátia Gomes, Jason S. Meyer
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Handb Exp Pharmacol. 2023;281:83-102. doi: 10.1007/164_2023_642.
Enhanced mitochondrial biogenesis promotes neuroprotection in human pluripotent stem cell derived retinal ganglion cells
Michelle Surma, Kavitha Anbarasu, Sayanta Dutta, Leonardo J Olivera Perez, Kang-Chieh Huang, Jason S. Meyer, Arupratan Das
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Communications Biology 2023; 6(1):218. doi: 10.1038/s42003-023-04576-w.
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells
Cátia Gomes*, Kirstin B. VanderWall*, Yanling Pan, Xiaoyu Lu, Sailee S. Lavekar, Kang-Chieh Huang, Clarisse M. Fligor, Jade Harkin, Chi Zhang, Theodore R. Cummins, Jason S. Meyer
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Stem Cell Reports 2022; 17(7):1636-1649. doi: 10.1016/j.stemcr.2022.05.006.
Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids
Clarisse M Fligor, Sailee S Lavekar, Jade Harkin, Priya K Shields, Kirstin B VanderWall, Kang-Chieh Huang, Cátia Gomes, Jason S. Meyer
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Stem Cell Reports 2022; 16(9):2228-2241. doi: 10.1016/j.stemcr.2021.05.009
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Differential susceptibility of retinal ganglion cell subtypes in acute and chronic models of injury and disease
Kirstin B. VanderWall, Bin Lu, Jorge S Alfaro, Anna R Allsop, Alexa S Carr, Shaomei Wang, Jason S. Meyer
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Scientific Reports 2021; 10(1):17359. doi: 10.1038/s41598-020-71460-6.
Differentiation of retinal organoids from human pluripotent stem cells
Clarisse M. Fligor, Kang-Chieh Huang, Sailee S. Lavekar, Kirstin B. VanderWall, Jason S. Meyer
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Methods in Cell Biology 2020; 159:279-302. doi: 10.1016/bs.mcb.2020.02.005.
Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids
Kirstin B VanderWall, Kang-Chieh Huang, Yanling Pan, Sailee S Lavekar, Clarisse M Fligor, Anna R Allsop, Kelly A Lentsch, Pengtao Dang, Chi Zhang, Henry C Tseng, Theodore R Cummins, Jason S Meyer
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Stem Cell Reports 2020; 15(1):52-66. doi: 10.1016/j.stemcr.2020.05.009.
Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors
Ana Artero-Castro, Francisco Javier Rodriguez-Jimenez, Pavla Jendelova, Kirstin B VanderWall, Jason S Meyer, Slaven Erceg
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Progress in Neurobiology 2020; 193:101817. doi: 10.1016/j.pneurobio.2020.101817.
Mouse g-synuclein promoter-mediated gene expression and editing in mammalian retinal ganglion cells
Qizhao Wang, Pei Zhuang, Haoliang Huang, Liang Li, Liang Liu, Hannah C Webber, Roopa Dalal, Leonand Siew, Clarisse M. Fligor, Kun-Che Chang, Michael Nahmou, Alexander Kreymerman, Yang Sun, Jason S. Meyer, Jeffrey L. Goldberg, Yang Hu
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J. Neurosci 2020; 40(20):3896-3914. doi: 10.1523/JNEUROSCI.0102-20-2020.
Energy metabolism and mitochondrial superoxide anion production in pre-symptomatic striatal neurons derived from human induced pluripotent stem cells expressing mutant Huntingtin
James Hamilton, Tatiana Brustovetsky, Akshayalakshmi Sridhar, Yanling Pan, Theodore R. Cummins, Jason S. Meyer, Nickolay Brustovetsky
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Mol Neurobiol 2020; 57(2): 668-684. doi: 10.1007/s12035-019-01734-2.
Advances in the differentiation of retinal ganglion cells from human pluripotent stem cells
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Adv Exp Med Biol 2019; 1186:121-140. doi: 10.1007/978-3-030-28471-8_5
Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells
Kirstin B VanderWall, Ridhima Vij, Sarah K Ohlemacher, Akshayalakshmi Sridhar, Clarisse M Fligor, Elyse M Feder, Michael C Edler, Anthony J Baucum 2nd, Theodore R Cummins, Jason S Meyer​
Stem Cell Reports 2019; 12(2): 201-212. doi: 10.1016/j.stemcr.2018.12.010.
Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells
Clarisse M. Fligor, Kirstin B. Langer, Akshayalakshmi Sridhar, Yuan Ren, Priya K Shields, Michael C. Edler, Sarah K. Ohlemacher, Valentin M Sluch, Donald J Zack, Chi Zhang, Daniel M Suter, Jason S. Meyer
Scientific Reports 2018; 8(1):14520. doi: 10.1038/s41598-018-32871-8.
Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells
Kirstin B. Langer, Sarah K. Ohlemacher, M Joseph Phillips, Clarisse M Fligor, Peng Jiang, David M. Gamm, Jason S. Meyer
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Stem Cell Reports 2018; 10(4): 1282-1293. doi: 10.1016/j.stemcr.2018.02.010.
Modeling CNS Development and Disease
Jason P. Weick, Jason S. Meyer, Julia Ladewig, Weixiang Guo, Yan Liu
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Stem Cells Int 2016; 2016:3241057. doi: 10.1155/2016/3241057.
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Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration
Sarah K. Ohlemacher, Akshayalakshmi Sridhar, Yucheng Xiao, Alexandra E. Hochstetler, Mansoor Sarfarazi, Theodore R. Cummins, Jason S. Meyer​
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Stem Cells 2016; 34(6): 1553-62. doi: 10.1002/stem.2356.
Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage
Akshayalakshmi Sridhar, Sarah K Ohlemacher, Kirstin B Langer, Jason S. Meyer
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Stem Cells Transl Med 2016; 5(4): 417-26. doi: 10.5966/sctm.2015-0093.
Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells: Applications for the Study and Treatment of Optic Neuropathies
Jessica A. Cooke, Jason S. Meyer
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Curr Ophthalmol Rep 2015; 3(3): 200-206. doi: 10.1007/s40135-015-0081-9.
Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells
Sarah K Ohlemacher, Clara L Iglesias, Akshayalakshmi Sridhar, David M Gamm, Jason S. Meyer
Curr Protoc Stem Cell Biol 2015; 32:1H.8.1-1H.8.20. doi: 10.1002/9780470151808.sc01h08s32.
Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation
Capowski EE, Simonett JM, Clark EM, Wright LS, Howden SE, Wallace KA, Petelinsek AM, Pinilla I, Phillips MJ, Meyer JS, Schneider BL, Thomson JA, Gamm DM
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Hum Mol Genet 2014; 23(23):6332-44. doi: 10.1093/hmg/ddu351.
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
Xiaofeng Zhong, Christian Gutierrez, Tian Xue, Christopher Hampton, M. Natalia Vergara, Li-Hui Cao, Ann Peters, Tea Soon Park, Elias T. Zambidis, Jason S. Meyer, David M. Gamm, Kin-Wai Yau, M. Valeria Canto-Soler
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Nat Commun 2014; 5:4047. doi: 10.1038/ncomms5047.
Neural regeneration
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Steward MM, Sridhar A, Meyer JS
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Curr Top Microbiol Immunol 2013; 367:163-91. doi: 10.1007/82_2012_302.
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Nonxenogeneic growth and retinal differentiation of human induced pluripotent stem cells
Sridhar A, Steward MM, Meyer JS
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Stem Cells Transl Med 2013; 2(4):255-64. doi: 10.5966/sctm.2012-0101.
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Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment
Jason S Meyer, Sara E Howden, Kyle A Wallace, Amelia D Verhoeven, Lynda S Wright, Elizabeth E Capowski, Isabel Pinilla, Jessica M Martin, Shulan Tian, Ron Stewart, Bikash Pattnaik, James A Thomson, David M Gamm
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Stem Cells 2011; 29(8):1206-18. doi: 10.1002/stem.674.​
Modeling early retinal development with human embryonic and induced pluripotent stem cells
Jason S Meyer, Rebecca L Shearer, Elizabeth E Capowski, Lynda S Wright, Kyle A Wallace, Erin L McMillan, Su-Chun Zhang, David M Gamm
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Proc Natl Acad Sci 2009; 106(39):16698-703. doi: 10.1073/pnas.0905245106.​
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Detection of calcium transients in embryonic stem cells and their differentiated progeny
Jason S Meyer, Gregory Tullis, Christopher Pierret, Kathleen M Spears, Jason A Morrison, Mark D Kirk
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Cell Mol Neurobiol 2009; 29(8):1191-203. doi: 10.1007/s10571-009-9413-3.​
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Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1
David M Gamm, Lynda S Wright, Elizabeth E Capowski, Rebecca L Shearer, Jason S Meyer, Hyun-Jung Kim, Bernard L Schneider, John Nicholas Melvan, Clive N Svendsen
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Stem Cells 2008; 26(12):3182-93. doi: 10.1634/stemcells.2008-0300.​
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Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photore
Jason S Meyer, Martin L Katz, Joel A Maruniak, Mark D Kirk
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Stem Cells 2006; 24(2): 274-83. 10.1634/stemcells.2005-0059.​
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Stem cells for retinal degenerative disorders
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Jason S Meyer, Martin L Katz, Mark D Kirk
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Ann NY Acad Sci 2005; 1049:135-45. doi: 10.1196/annals.1334.013.​
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Neural differentiation of mouse embryonic stem cells in vitro and after transplantation into eyes of mutant mice with rapid retinal degeneration
Jason S Meyer, Martin L Katz, Joel A Maruniak, Mark D Kirk
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Brain Res 2004; 1014(1-2):131-44. doi: 10.1016/j.brainres.2004.04.019.​
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Dichotomy in phasic-tonic neuromuscular structure of crayfish inhibitory axons
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Mark D Kirk, Jason S Meyer, Mark W Miller, CK Govind
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J Comp Neurol 2001; 435(3):283-90. doi: 10.1002/cne.1030.​
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